CANCER FAMILY HISTORY AND THEIR OUTCOMES

Does family history of prostate cancer affect outcomes following radiotherapy?

OBJECTIVE To examine family history (FH) as a prognostic factor following radiotherapy (RT). MATERIALS AND METHODS Between 1989 and 2007, 1711 men with clinically localized prostate cancer and complete family history who had received RT (median RT dose=74Gy) without androgen deprivation therapy were analyzed. FH was defined as any prostate cancer in a first degree relative. For the biochemica...

Gastric cancer and family history

Gastric cancer is associated with high morbidity and mortality rates worldwide. Identifying individuals at high risk is important for surveillance and prevention of gastric cancer. Having first-degree relatives diagnosed with gastric cancer is a strong and consistent risk factor for gastric cancer, but the pathogenic mechanisms behind this familial aggregation are unclear. Against this backgrou...

family history of colorectal cancer in iran

introduction and aims: previous reports show a high proportion of young crc patients in iran. in this study we aim to look for the clustering of colorectal cancer in families of a series of crc patients from iran. materials and methods: the family history of cancer is traced in 449 crc patients of which 112 were 45 years or younger and 337 were older than 45years at time of diagnosis. the patie...

Family history and risk of breast cancer.

The risk of breast cancer in first degree relatives of patients with breast cancer can be derived from family history and is dependent upon the age at diagnosis in the index patient. For the relatives of index patients older than 55, the relative risk is 1.57, if less than 55 the relative risk is 2.29, and 3.85 if less than 45 (95% confidence limits 0.83 to 2.68, 1.18 to 4.01, and 1.67 to 3.85,...

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